Cellular responses of histatin-derived peptides immobilized titanium surface using a tresyl chloride-activated method
نویسندگان
چکیده
Effects of histatin-derived peptides immobilization by tresyl chloride-activation technique for MC3T3-E1 cellular responses on titanium (Ti) were evaluated. cultured sandblasted and acid-etched Ti disks immobilized with peptides, including histatin-1, JH8194, mixed histatin-1 JH8194. Surface topography morphology examined using a scanning electron microscope. Elemental composition conformational surface energy dispersive X-ray fourier transform infrared spectroscopy, respectively. Cellular adhesion, proliferation, osteogenesis-related genes, alkaline phosphatase activity The results showed that successfully surface. Cell attachments coated groups are higher than control. Histatin-1 achieved the significantly highest proliferation. Histatin-derived improved osteogenesis related-gene expression (p<0.05). This study suggested enhanced might be able to promote activities around dental implants.
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ژورنال
عنوان ژورنال: Dental Materials Journal
سال: 2021
ISSN: ['0287-4547', '1881-1361']
DOI: https://doi.org/10.4012/dmj.2020-307